1. Do a "from everywhere" month wide search to your destination on Skyscanner.com. This will tell you which airlines and routes are the cheapest into this airport.
2. Do a "to everywhere" month wide search from your home airport on Skyscanner.com. This will show you which airlines and routes are the cheapest out of your home airport.
3. Determine the cheapest common airline and airport between your home airport and your destination. This will be your layover airport.
4. Book two one way tickets, one to your layover airport, and one from there to your destination.
5. Make sure you create a long enough layover to accommodate possible delays, to retrieve checked bags, and to pass back through security.
For a more in depth explanation and an example, see this post - How I buy tickets to Iceland for Less
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